HCAR3

Across TCGA patient cohorts, HCAR3 mutation is significantly associated with the RNA expression of many other genes, with 4,231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCAR3-associated genes across cancer lineages are SNORD66, RPL23AP82, and COX6B1P6. Each is linked with HCAR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR3-to-partner and partner-to-HCAR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD66 grouped by HCAR3-low versus HCAR3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR3→partner) and Y-score (partner→HCAR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORD66 →	+0.858	+4.268	<.001	.008	3	2
UCEC	RPL23AP82 →	+0.390	+1.936	<.001	.003	3	2
BLCA	COX6B1P6 →	+0.192	+4.429	.002	.006	3	2
BLCA	RN7SL88P →	+0.251	+5.017	<.001	.002	3	2
STAD	TTTY7 →	+0.084	+5.366	<.001	.005	3	2
COAD	RN7SKP281 →	+0.336	+3.778	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,231 associations by consensus.

SNORD66 by HCAR3 expression — BLCA

Explore this box plot interactively →