HCAR3

Across TCGA patient cohorts, HCAR3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCAR3-associated genes across cancer lineages are Caspase-8, Notch1, and p62 Lck ligand. Each is linked with HCAR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR3-to-partner and partner-to-HCAR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by HCAR3-low versus HCAR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR3→partner) and Y-score (partner→HCAR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.223	-2.906	.020	.001	3	2
UCEC	Notch1 →	+0.166	+2.594	.002	.006	3	1
UCEC	p62 Lck ligand →	+0.338	+1.678	.006	.023	3	1
UCEC	P-Cadherin →	-0.127	-3.169	.021	.018	3	1
UCEC	STAT3_pY705 →	-0.323	-1.678	.001	.023	3	1
UCEC	Tuberin →	+0.258	+2.331	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Caspase-8 by HCAR3 expression — UCEC

Explore this box plot interactively →