HBZ

Across TCGA patient cohorts, HBZ protein abundance is significantly associated with the RNA expression of many other genes, with 3,997 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HBZ-associated genes across cancer lineages are HBA2, HBA1, and PF4. Each is linked with HBZ in more than 5 cancer types. Because this analysis shows association rather than direction, both HBZ-to-partner and partner-to-HBZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HBZ versus HBA2 in LSCC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBZ→partner) and Y-score (partner→HBZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HBA2 →	+1.749	+0.401	<.001	<.001	3	6
GBM	HBA1 →	+1.352	+1.049	<.001	<.001	3	6
GBM	PF4 →	+0.756	+0.844	<.001	<.001	3	5
LSCC	HBB →	+1.763	+0.424	<.001	<.001	3	5
PDAC	CXCR2 →	+0.839	+0.990	.005	.006	3	4
CCRCC	HEMGN →	+0.606	+0.846	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,997 associations by consensus.

HBZ vs HBA2 — LSCC

Explore this scatter interactively →