HBS1L

Across TCGA patient cohorts, HBS1L mutation is significantly associated with the RNA expression of many other genes, with 4,157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBS1L-associated genes across cancer lineages are MRPS18C, PSMD9, and TNK1. Each is linked with HBS1L in more than 2 cancer types. Because this analysis shows association rather than direction, both HBS1L-to-partner and partner-to-HBS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS18C grouped by HBS1L-low versus HBS1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBS1L→partner) and Y-score (partner→HBS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS18C →	+0.398	+2.705	<.001	<.001	3	3
UCEC	PSMD9 →	+0.367	+2.016	<.001	<.001	3	3
UCEC	TNK1 →	+0.334	+1.964	.008	<.001	3	3
UCEC	GLRX5 →	+0.371	+1.986	<.001	<.001	3	3
SKCM	MRGPRX6P →	+0.034	+4.884	<.001	.004	3	2
COAD	GPI →	+0.586	+3.713	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,157 associations by consensus.

MRPS18C by HBS1L expression — UCEC

Explore this box plot interactively →