Across TCGA patient cohorts, HBG1 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HBG1-associated genes across cancer lineages are RPS26P30, PRUNEP1, and TRAPPC13P1. Each is linked with HBG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBG1-to-partner and partner-to-HBG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBG1→partner) and Y-score (partner→HBG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS26P30 →	+0.212	+5.283	.009	.006	3	2
SKCM	PRUNEP1 →	+0.034	+2.406	<.001	.004	3	1
SKCM	TRAPPC13P1 →	+0.082	+1.937	.001	.008	3	1
SKCM	OR2AF1P →	+0.048	+2.662	<.001	.005	3	1
SKCM	OR9A1P →	+0.033	+2.853	<.001	<.001	3	1
SKCM	OR11Q1P →	+0.205	+3.106	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Exploration

HBG1 survival (RNA) · tumor vs normal (RNA) · all HBG1 data types