HBEGF

Across TCGA patient cohorts, HBEGF mutation is significantly associated with the RNA expression of many other genes, with 1,419 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBEGF-associated genes across cancer lineages are TEMN3-AS1, MIR6803, and RNU6-873P. Each is linked with HBEGF in more than 1 cancer types. Because this analysis shows association rather than direction, both HBEGF-to-partner and partner-to-HBEGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEMN3-AS1 grouped by HBEGF-low versus HBEGF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBEGF→partner) and Y-score (partner→HBEGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TEMN3-AS1 →	+0.181	+2.644	<.001	.005	3	2
UCEC	MIR6803 →	+0.144	+4.390	<.001	.003	3	2
STAD	RNU6-873P →	+0.831	+5.105	<.001	.008	3	2
STAD	MIR4536-2 →	+0.342	+5.274	<.001	.006	3	2
COAD	RNU6-709P →	+0.992	+7.142	<.001	<.001	3	2
SKCM	RNA5SP66 →	+0.263	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,419 associations by consensus.

TEMN3-AS1 by HBEGF expression — UCEC

Explore this box plot interactively →