HBEGF

Across TCGA pan-cancer cohorts, HBEGF RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HBEGF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where HBEGF RNA is repressed in tumor relative to normal tissue. In most cancer types HBEGF is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and LUSC are the cancer types where HBEGF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HBEGF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−2.345	<.001	11	view →
KICH	All	III,IV	−3.572	<.001	10	view →
LUSC	Female	II,III,IV	−2.724	<.001	8	view →
LUAD	Female	All	−2.360	<.001	8	view →
BLCA	All	All	−2.106	<.001	8	view →
KIRC	All	III,IV	−0.800	<.001	7	view →
UCEC	All	All	−1.669	<.001	6	view →
BRCA	All	III,IV	−1.048	<.001	6	view →
CHOL	All	All	+1.062	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HBEGF–KIRP

Open the KIRP breakdown →