HBEGF

Across TCGA cell cohorts, HBEGF mutation is significantly associated with the mutation status of many other genes, with 1,437 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HBEGF-associated genes across cancer lineages are DLX2, C2, and KBTBD3. Each is linked with HBEGF in more than 2 cancer types. Because this analysis shows association rather than direction, both HBEGF-to-partner and partner-to-HBEGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLX2 grouped by HBEGF-low versus HBEGF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBEGF→partner) and Y-score (partner→HBEGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DLX2 →	+5.087	+4.523	.006	.006	1	3
LARGE_INTESTINE	C2 →	+5.672	+5.672	<.001	<.001	1	3
LARGE_INTESTINE	KBTBD3 →	+3.672	+4.799	.002	.002	1	3
LARGE_INTESTINE	OR2A25 →	+5.087	+4.523	.006	.006	1	3
LARGE_INTESTINE	TXNDC16 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	ANAPC5 →	+4.087	+5.044	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,437 associations by consensus.

DLX2 by HBEGF expression — LARGE_INTESTINE

Explore this box plot interactively →