Across TCGA patient cohorts, HBD RNA expression is significantly associated with the protein abundance of many other proteins, with 5,759 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HBD-associated proteins across cancer lineages are RASGRP2_S576, RFESD, and SPTA1_S1284. Each is linked with HBD in more than 3 cancer types. Because this analysis shows association rather than direction, both HBD-to-partner and partner-to-HBD results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HBD→partner) and Y-score (partner→HBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASGRP2_S576 →	+0.794	+0.249	.007	<.001	3	3
PDAC	RFESD →	+0.771	+0.262	.004	.003	3	3
CCRCC	SPTA1_S1284 →	+1.324	+0.821	<.001	<.001	3	3
GBM	SPTLC1 →	-0.280	-0.218	<.001	.002	3	3
HNSC	MYO1G →	+0.431	+0.859	<.001	.006	3	3
BRCA	MZB1 →	+1.141	+0.285	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,759 associations by consensus.

Exploration

HBD survival (RNA) · tumor vs normal (RNA) · all HBD data types