HBB

Across TCGA pan-cancer cohorts, HBB mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated HBB data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HBB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HBB expression acts as an unfavorable survival marker.

PDAC are the cancer types where HBB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.454	0.911	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

HBB–PDAC (OS)

Open the PDAC breakdown →