HBB

Across TCGA pan-cancer cohorts, HBB RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HBB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HBB RNA is repressed in tumor relative to normal tissue. In most cancer types HBB is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and LUSC are the cancer types where HBB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HBB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−3.966	<.001	11	view →
THCA	All	IV	−3.637	<.001	11	view →
LUSC	Female	II,III,IV	−5.901	<.001	9	view →
LUAD	Male	III,IV	−4.830	<.001	9	view →
STAD	All	II,III,IV	−2.792	<.001	7	view →
LIHC	Male	All	−1.818	<.001	7	view →
BRCA	All	III,IV	−4.194	<.001	6	view →
KICH	All	II,III,IV	−2.165	<.001	6	view →
UCEC	All	All	−2.089	<.001	6	view →
KIRP	All	All	−1.457	.003	4	view →
CHOL	All	All	−2.493	<.001	3	view →
BLCA	Female	IV	−1.210	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HBB–COAD

Open the COAD breakdown →