HBB

Across TCGA cell cohorts, HBB RNA expression is significantly associated with the go_rna of many other GO terms, with 1,899 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HBB-associated GO terms across cancer lineages are Oxygen transport, Carbon dioxide transport, and snoRNA guided rRNA pseudouridine synthesis. Each is linked with HBB in more than 5 cancer types. Because this analysis shows association rather than direction, both HBB-to-partner and partner-to-HBB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxygen transport grouped by HBB-low versus HBB-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HBB→partner) and Y-score (partner→HBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Oxygen transport →	+1.268	+4.996	<.001	<.001	3	6
LUNG_SCLC	Carbon dioxide transport →	+2.266	+5.256	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	snoRNA guided rRNA pseudouridine synthesis →	+0.074	+0.380	.004	.008	2	6
BREAST	Regulation of myotube differentiation →	-0.085	-0.297	<.001	.006	3	5
SKIN	Protein localization to microtubule plus-end →	-0.129	-0.204	<.001	.001	3	4
SKIN	Protein localization to microtubule end →	-0.129	-0.204	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,899 associations by consensus.

Oxygen transport by HBB expression — LUNG_SCLC

Explore this box plot interactively →