HAX1

Across TCGA pan-cancer cohorts, HAX1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HAX1 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HAX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HAX1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where HAX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.248	0.863	<.001	33	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	12	view →
LUAD	DFS	Median	II,III,IV	0.970	0.736	.008	9	view →
LSCC	DFS	Median	III,IV	0.944	0.626	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HAX1–CCRCC (DFS)

Open the CCRCC breakdown →