HAX1

Across TCGA pan-cancer cohorts, HAX1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HAX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HAX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HAX1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where HAX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.549	<.001	12	view →
LIHC	Male	II,III,IV	+1.401	<.001	9	view →
HNSC	All	III,IV	+0.454	<.001	9	view →
THCA	All	All	−0.198	<.001	9	view →
LUAD	Male	All	+0.582	<.001	8	view →
COAD	Female	II,III,IV	+0.525	<.001	8	view →
BRCA	All	III,IV	+0.647	<.001	6	view →
KICH	Female	All	−0.925	<.001	5	view →
LUSC	All	All	+0.457	<.001	5	view →
CHOL	Male	All	+1.713	<.001	3	view →
BLCA	Female	III,IV	+0.418	.013	3	view →
ESCA	All	All	+0.540	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HAX1–KIRC

Open the KIRC breakdown →