HAX1

Across TCGA patient cohorts, HAX1 mutation is significantly associated with the RNA expression of many other genes, with 1,223 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAX1-associated genes across cancer lineages are C11orf54, MTFMT, and EIF3J. Each is linked with HAX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAX1-to-partner and partner-to-HAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C11orf54 grouped by HAX1-low versus HAX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAX1→partner) and Y-score (partner→HAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C11orf54 →	+0.579	+2.332	<.001	.003	3	2
UCEC	MTFMT →	+0.458	+3.000	<.001	.001	3	2
UCEC	EIF3J →	+0.574	+2.321	.001	.006	3	2
UCEC	PPIL4 →	+0.581	+2.332	.005	.003	3	2
UCEC	RPA1 →	+0.653	+3.708	<.001	<.001	3	2
UCEC	COG6 →	+0.547	+3.191	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,223 associations by consensus.

C11orf54 by HAX1 expression — UCEC

Explore this box plot interactively →