HAX1

Across TCGA patient cohorts, HAX1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAX1-associated genes across cancer lineages are 4E-BP1, FOXO3a_pS318_S321, and JNK2. Each is linked with HAX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAX1-to-partner and partner-to-HAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HAX1-low versus HAX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAX1→partner) and Y-score (partner→HAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.335	+2.199	.006	.033	3	2
UCEC	FOXO3a_pS318_S321 →	-0.145	-2.321	.010	.033	3	1
UCEC	JNK2 →	+0.322	+2.700	<.001	.006	3	1
UCEC	Ku80 →	+0.284	+3.331	.007	.005	3	1
UCEC	MEK1 →	+0.409	+3.169	.013	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.478	-2.321	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

4E-BP1 by HAX1 expression — UCEC

Explore this box plot interactively →