HAT1

Across TCGA pan-cancer cohorts, HAT1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HAT1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HAT1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HAT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where HAT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	47	view →
CCRCC	OS	Median	IV	0.123	0.785	.009	24	view →
PDAC	OS	Quartile	II,III,IV	0.629	1.000	.002	10	view →
LSCC	DFS	Tertile	All	0.860	0.322	.019	9	view →
LUAD	OS	Quartile	All	0.572	1.000	.003	8	view →
OV	DFS	Median	All	0.864	1.000	.030	4	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.527	.048	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HAT1–HNSC (OS)

Open the HNSC breakdown →