HAT1

Across TCGA pan-cancer cohorts, HAT1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HAT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HAT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HAT1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where HAT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.942	<.001	12	view →
LIHC	Male	II,III,IV	+1.163	<.001	9	view →
KICH	Female	II,III,IV	−1.969	<.001	8	view →
STAD	Male	II,III,IV	+0.778	<.001	8	view →
LUSC	Female	All	+0.981	<.001	7	view →
COAD	Male	All	+0.424	<.001	7	view →
BLCA	All	All	+0.499	.001	6	view →
BRCA	All	III,IV	+0.491	<.001	6	view →
THCA	All	All	−0.316	<.001	6	view →
CHOL	Male	All	+1.688	<.001	5	view →
LUAD	Male	II,III,IV	+0.440	<.001	5	view →
READ	All	All	+0.341	.011	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HAT1–HNSC

Open the HNSC breakdown →