HAT1

Across TCGA patient cohorts, HAT1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAT1-associated genes across cancer lineages are p27_pT198, PKC-delta_pS664, and A-Raf_pS299. Each is linked with HAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAT1-to-partner and partner-to-HAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by HAT1-low versus HAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAT1→partner) and Y-score (partner→HAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.092	+2.321	.049	.034	3	2
UCEC	PKC-delta_pS664 →	-0.121	-3.459	.021	.005	3	2
UCEC	A-Raf_pS299 →	-0.173	-3.459	<.001	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.134	-1.874	.013	.049	3	1
UCEC	JNK_pT183_Y185 →	-0.178	-2.321	.015	.034	3	1
UCEC	JNK2 →	+0.305	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p27_pT198 by HAT1 expression — UCEC

Explore this box plot interactively →