HAS2

Across TCGA cell cohorts, HAS2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAS2-associated genes across cancer lineages are CSN2, FAM71C, and GUCA2A. Each is linked with HAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAS2-to-partner and partner-to-HAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by HAS2-low versus HAS2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAS2→partner) and Y-score (partner→HAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSN2 →	+0.091	+4.415	<.001	.007	3	1
SKIN	FAM71C →	+0.015	+4.095	.001	.009	3	1
SKIN	GUCA2A →	+0.052	+4.273	.009	.006	3	1
SKIN	SPINK9 →	+0.043	+4.415	<.001	.007	3	1
BREAST	MEIKIN →	+0.099	+5.169	.004	.005	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CSN2 by HAS2 expression — SKIN

Explore this box plot interactively →