HAS2

Across TCGA pan-cancer cohorts, HAS2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HAS2 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HAS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HAS2 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

KIRP, LUSC, and SARC are the cancer types where HAS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.293	0.799	<.001	114	view →
LUSC	OS	Median	II,III,IV	0.293	0.502	<.001	53	view →
SARC	DFS	Median	All	0.204	0.546	<.001	36	view →
LGG	DFS	Quartile	All	0.760	0.896	.001	36	view →
OV	DFS	Tertile	II,III,IV	0.471	0.589	.005	34	view →
SKCM	DFS	Median	IV	0.067	0.732	.001	31	view →
DLBC	DFS	Median	All	0.606	1.000	.011	25	view →
UVM	OS	Quartile	All	1.000	0.675	.010	23	view →
MESO	OS	Median	II,III,IV	0.482	0.626	.011	20	view →
STAD	DFS	Median	All	0.307	0.503	.002	20	view →
KICH	OS	Tertile	II,III,IV	0.764	1.000	.023	17	view →
THCA	DFS	Median	III,IV	0.611	0.876	.004	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HAS2–KIRP (OS)

Open the KIRP breakdown →