HAS2-AS1

Across TCGA pan-cancer cohorts, HAS2-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HAS2-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HAS2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HAS2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and THCA show a favorable association.

KIRP, KIRC, and MESO are the cancer types where HAS2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.837	0.952	<.001	70	view →
KIRC	DFS	Tertile	All	0.559	0.691	.005	35	view →
MESO	OS	Tertile	All	0.214	0.675	.006	29	view →
SARC	OS	Median	All	0.645	0.869	<.001	26	view →
ACC	OS	Quartile	All	0.733	0.974	.004	20	view →
STAD	DFS	Tertile	IV	0.191	0.670	.019	17	view →
LIHC	OS	Tertile	All	0.422	0.606	.004	17	view →
SKCM	DFS	Median	IV	0.223	0.631	.036	12	view →
LUAD	OS	Tertile	All	0.693	0.863	.006	12	view →
OV	DFS	Tertile	II,III,IV	0.354	0.432	.041	10	view →
HNSC	OS	Tertile	All	0.716	0.797	.008	7	view →
UVM	OS	Quartile	II,III,IV	1.000	0.510	.003	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HAS2-AS1–KIRP (OS)

Open the KIRP breakdown →