HAS2-AS1

Across TCGA pan-cancer cohorts, HAS2-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HAS2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HAS2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HAS2-AS1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where HAS2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAS2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.616	<.001	9	view →
KIRC	All	All	−0.167	.001	6	view →
BRCA	All	II,III,IV	−0.312	<.001	4	view →
KIRP	All	All	−0.158	.001	3	view →
KICH	Female	All	−0.570	<.001	2	view →
PRAD	All	All	−0.359	<.001	2	view →
LUSC	Male	III,IV	−0.745	.002	1	view →
LUAD	All	III,IV	−0.386	.036	1	view →
CHOL	Female	All	+0.206	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HAS2-AS1–HNSC

Open the HNSC breakdown →