Across TCGA patient cohorts, HAPLN4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,351 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HAPLN4-associated genes across cancer lineages are PRODH, NEFH, and SYNGR1. Each is linked with HAPLN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAPLN4-to-partner and partner-to-HAPLN4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN4→partner) and Y-score (partner→HAPLN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.699	+0.467	.005	<.001	3	1
GBM	NEFH →	+1.381	+0.500	<.001	<.001	3	1
GBM	SYNGR1 →	+0.801	+0.469	.001	<.001	3	1
GBM	PNPLA5 →	+0.303	+0.421	<.001	.002	3	1
GBM	CACNA1I →	+0.722	+0.530	<.001	<.001	3	1
GBM	PVALB →	+1.146	+0.467	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,351 associations by consensus.

Exploration

HAPLN4 survival (RNA) · tumor vs normal (RNA) · all HAPLN4 data types