Across TCGA patient cohorts, HAPLN4 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAPLN4-associated genes across cancer lineages are Notch1, EGFR_pY1068, and Ku80. Each is linked with HAPLN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAPLN4-to-partner and partner-to-HAPLN4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN4→partner) and Y-score (partner→HAPLN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.171	+2.820	.020	.035	3	2
UCEC	EGFR_pY1068 →	-0.295	-3.000	.024	.036	3	1
UCEC	Ku80 →	+0.347	+3.009	.005	.019	3	1
UCEC	MEK1 →	+0.413	+3.000	.031	.036	3	1
UCEC	p27_pT157 →	-0.077	-3.321	.011	.010	3	1
UCEC	p62 Lck ligand →	+0.722	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

HAPLN4 survival (RNA) · tumor vs normal (RNA) · all HAPLN4 data types