HAPLN3

Across TCGA pan-cancer cohorts, HAPLN3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HAPLN3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HAPLN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HAPLN3 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

COAD, LSCC, and LUAD are the cancer types where HAPLN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	0.764	1.000	.024	42	view →
LSCC	OS	Quartile	II,III,IV	0.544	0.911	.007	13	view →
LUAD	OS	Median	All	0.785	0.897	.030	3	view →
GBM	OS	Quartile	All	0.581	0.349	.035	3	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →
PDAC	DFS	Tertile	All	0.847	0.695	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HAPLN3–COAD (DFS)

Open the COAD breakdown →