HAPLN2

Across TCGA patient cohorts, HAPLN2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,697 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HAPLN2-associated genes across cancer lineages are SOX10, NEFH, and RASD2. Each is linked with HAPLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAPLN2-to-partner and partner-to-HAPLN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HAPLN2 versus SOX10 in GBM, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN2→partner) and Y-score (partner→HAPLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOX10 →	+1.595	+0.970	<.001	<.001	3	1
GBM	NEFH →	+0.928	+0.803	.001	<.001	3	1
GBM	RASD2 →	+0.752	+1.107	<.001	<.001	3	1
GBM	PNPLA5 →	+0.255	+0.692	.001	<.001	3	1
GBM	CACNA1I →	+0.540	+0.762	.003	<.001	3	1
GBM	PVALB →	+1.034	+0.832	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,697 associations by consensus.

HAPLN2 vs SOX10 — GBM

Explore this scatter interactively →