HAPLN2

Across TCGA pan-cancer cohorts, HAPLN2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HAPLN2 data layer compared with 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HAPLN2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HAPLN2 expression acts as an unfavorable survival marker, although some lineages such as THCA and KICH show a favorable association.

COAD, THCA, and ACC are the cancer types where HAPLN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	0.519	0.843	<.001	72	view →
THCA	DFS	Median	All	0.942	0.849	<.001	49	view →
ACC	DFS	Quartile	All	0.185	0.722	<.001	49	view →
MESO	OS	Quartile	All	0.292	0.552	.014	43	view →
LUAD	DFS	Tertile	II,III,IV	0.340	0.629	.002	41	view →
KIRP	OS	Quartile	All	0.509	0.879	.001	32	view →
KICH	OS	Median	All	1.000	0.851	.002	23	view →
UCS	DFS	Median	II,III,IV	0.536	0.186	.006	18	view →
HNSC	OS	Tertile	IV	0.573	0.331	.002	16	view →
DLBC	DFS	Tertile	All	0.182	1.000	.006	14	view →
ESCA	DFS	Tertile	IV	0.252	0.704	.024	12	view →
BLCA	OS	Quartile	All	0.533	0.340	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HAPLN2–COAD (DFS)

Open the COAD breakdown →