HAPLN2

Across TCGA cell cohorts, HAPLN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,119 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HAPLN2-associated GO terms across cancer lineages are Base-excision repair, gap-filling, Regulation of myoblast fusion, and Copper ion export. Each is linked with HAPLN2 in more than 8 cancer types. Because this analysis shows association rather than direction, both HAPLN2-to-partner and partner-to-HAPLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Base-excision repair, gap-filling grouped by HAPLN2-low versus HAPLN2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN2→partner) and Y-score (partner→HAPLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Base-excision repair, gap-filling →	+0.109	+0.304	<.001	<.001	3	9
BONE	Regulation of myoblast fusion →	+0.085	+0.292	<.001	.001	3	8
BLOOD_Leukemia	Copper ion export →	-0.134	-0.302	<.001	.006	3	8
OVARY	Regulation of epinephrine secretion →	+0.916	+0.200	<.001	<.001	2	9
BLOOD_Lymphoma	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.048	+0.282	.001	<.001	3	8
LUNG_SCLC	Negative regulation of epinephrine secretion →	+0.902	+0.492	.002	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,119 associations by consensus.

Base-excision repair, gap-filling by HAPLN2 expression — BONE

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