HAP1

Across TCGA patient cohorts, HAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,641 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAP1-associated genes across cancer lineages are MTND3P16, MIR7975, and NUDT4B. Each is linked with HAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HAP1-to-partner and partner-to-HAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND3P16 grouped by HAP1-low versus HAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAP1→partner) and Y-score (partner→HAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTND3P16 →	+0.059	+3.307	<.001	.003	3	3
BRCA	MIR7975 →	+0.615	+4.800	<.001	.006	3	2
CESC	NUDT4B →	+0.049	+2.824	.007	.009	3	2
COAD	RNU6-393P →	+1.058	+5.917	<.001	.001	3	2
LIHC	RPL32P35 →	+0.130	+6.305	<.001	.001	3	2
CESC	RNU6-1220P →	+0.149	+4.252	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,641 associations by consensus.

MTND3P16 by HAP1 expression — UCEC

Explore this box plot interactively →