HAO2

Across TCGA pan-cancer cohorts, HAO2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HAO2 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HAO2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HAO2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD, GBM, and BLCA are the cancer types where HAO2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.111	0.851	<.001	9	view →
GBM	DFS	Median	All	0.048	0.257	.001	6	view →
BLCA	DFS	Median	All	0.205	0.597	.039	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	6	view →
SKCM	OS	Median	II,III,IV	0.932	0.719	.021	4	view →
LUSC	DFS	Median	All	0.165	0.707	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HAO2–COAD (OS)

Open the COAD breakdown →