HAO2

Across TCGA pan-cancer cohorts, HAO2 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated HAO2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HAO2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HAO2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC are the cancer types where HAO2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.972	0.566	.001	84	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

HAO2–CCRCC (OS)

Open the CCRCC breakdown →