HAO2

Across TCGA patient cohorts, HAO2 mutation is significantly associated with the RNA expression of many other genes, with 1,705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAO2-associated genes across cancer lineages are RPL7P40, LINC02002, and GEMIN7P1. Each is linked with HAO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HAO2-to-partner and partner-to-HAO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7P40 grouped by HAO2-low versus HAO2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO2→partner) and Y-score (partner→HAO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RPL7P40 →	+0.071	+5.925	.003	.002	3	2
READ	LINC02002 →	+0.028	+5.925	.001	.002	3	2
BLCA	GEMIN7P1 →	+0.174	+4.147	<.001	.009	3	2
BLCA	MIR4290HG →	+0.022	+4.251	<.001	.001	3	2
SKCM	GNG5 →	+0.269	+2.776	.009	.002	3	2
SKCM	HRAS →	+0.465	+2.623	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,705 associations by consensus.

RPL7P40 by HAO2 expression — READ

Explore this box plot interactively →