HAO2

Across TCGA cell cohorts, HAO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 890 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HAO2-associated GO terms across cancer lineages are Response to gamma radiation, Iron ion transmembrane transport, and Negative regulation of ubiquitin-dependent protein catabolic process. Each is linked with HAO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HAO2-to-partner and partner-to-HAO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to gamma radiation grouped by HAO2-low versus HAO2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO2→partner) and Y-score (partner→HAO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Response to gamma radiation →	-0.056	-0.061	.001	<.001	3	4
SKIN	Iron ion transmembrane transport →	+0.073	+0.053	.003	<.001	3	4
BLOOD_Myeloma	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.045	+0.036	.009	.009	3	4
KIDNEY	Regulation of phospholipid metabolic process →	+0.076	+0.033	.002	.002	3	4
SKIN	Aromatic amino acid transport →	+0.080	+0.054	.005	.003	2	4
SKIN	Response to aldosterone →	+0.161	+0.051	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 890 associations by consensus.

Response to gamma radiation by HAO2 expression — SKIN

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