HAO2

Across TCGA cell cohorts, HAO2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HAO2-associated genes across cancer lineages are C14orf177, SULT6B1, and TEX26. Each is linked with HAO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAO2-to-partner and partner-to-HAO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf177 grouped by HAO2-low versus HAO2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO2→partner) and Y-score (partner→HAO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C14orf177 →	+0.076	+4.922	<.001	.009	3	1
LUNG_NSCLC_LUAD	SULT6B1 →	+1.618	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	TEX26 →	+0.035	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	LRIT2 →	+0.029	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4A47 →	+0.029	+5.228	<.001	.005	3	1
SKIN	OR5AU1 →	+0.038	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C14orf177 by HAO2 expression — BLOOD_Leukemia

Explore this box plot interactively →