HAO2-IT1

Across TCGA pan-cancer cohorts, HAO2-IT1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated HAO2-IT1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HAO2-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HAO2-IT1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

BLCA, KICH, and ACC are the cancer types where HAO2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	IV	0.137	0.477	<.001	171	view →
KICH	OS	Tertile	II,III,IV	0.070	0.828	<.001	63	view →
ACC	DFS	Quartile	II,III,IV	0.166	0.561	<.001	48	view →
KIRC	DFS	Tertile	All	0.779	0.502	.001	46	view →
COAD	DFS	Tertile	All	0.170	0.790	.002	36	view →
ESCA	OS	Tertile	II,III,IV	0.522	0.714	.022	36	view →
CHOL	OS	Tertile	II,III,IV	0.019	0.675	<.001	36	view →
LIHC	DFS	Quartile	All	0.669	0.473	<.001	32	view →
PAAD	OS	Tertile	All	0.230	0.479	.032	18	view →
LGG	OS	Tertile	All	1.000	0.876	.035	6	view →
SKCM	OS	Tertile	All	0.689	0.789	.032	3	view →
MESO	OS	Quartile	IV	0.683	0.283	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

HAO2-IT1–BLCA (DFS)

Open the BLCA breakdown →