HAO2-IT1

Across TCGA pan-cancer cohorts, HAO2-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HAO2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where HAO2-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types HAO2-IT1 is over-expressed in tumor, although a few such as LIHC and KIRP show the opposite, repressed pattern.

LIHC, KIRP, and CHOL are the cancer types where HAO2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAO2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	−1.291	<.001	8	view →
KIRP	Male	All	−0.387	<.001	6	view →
CHOL	All	II,III,IV	−1.565	<.001	5	view →
KICH	All	All	−0.271	.001	5	view →
KIRC	All	All	−0.159	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HAO2-IT1–LIHC

Open the LIHC breakdown →