HAND1

Across TCGA patient cohorts, HAND1 protein abundance is significantly associated with the RNA expression of many other genes, with 508 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HAND1-associated genes across cancer lineages are PPP4R3A, NOP56, and POLA1. Each is linked with HAND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAND1-to-partner and partner-to-HAND1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HAND1 versus PPP4R3A in GBM, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND1→partner) and Y-score (partner→HAND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP4R3A →	+0.511	+0.790	.007	.006	3	1
GBM	NOP56 →	+0.688	+0.721	.001	.002	3	1
GBM	POLA1 →	+0.766	+0.740	.009	.003	3	1
GBM	SUV39H1 →	+0.718	+0.776	<.001	<.001	3	1
GBM	RBBP7 →	+0.398	+0.523	.003	.008	3	1
GBM	COG4 →	+0.448	+0.517	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 508 associations by consensus.

HAND1 vs PPP4R3A — GBM

Explore this scatter interactively →