HAGH

Across TCGA patient cohorts, HAGH mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAGH-associated genes across cancer lineages are Ku80, YB-1_pS102, and Caspase-7-cleavedD198. Each is linked with HAGH in more than 1 cancer types. Because this analysis shows association rather than direction, both HAGH-to-partner and partner-to-HAGH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by HAGH-low versus HAGH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAGH→partner) and Y-score (partner→HAGH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.390	+3.183	.002	.010	3	1
UCEC	YB-1_pS102 →	-0.205	-3.169	.043	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.962	+3.169	.003	.020	3	1
UCEC	cIAP →	+0.168	+3.196	.026	.010	3	1
UCEC	Rictor_pT1135 →	-0.141	-3.169	.012	.020	1	2
UCEC	eIF4G →	+0.426	+3.169	.012	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by HAGH expression — UCEC

Explore this box plot interactively →