HADHB

Across TCGA patient cohorts, HADHB mutation is significantly associated with the RNA expression of many other genes, with 851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HADHB-associated genes across cancer lineages are OR7A17, GUF1, and TMEM126A. Each is linked with HADHB in more than 2 cancer types. Because this analysis shows association rather than direction, both HADHB-to-partner and partner-to-HADHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7A17 grouped by HADHB-low versus HADHB-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HADHB→partner) and Y-score (partner→HADHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR7A17 →	+0.058	+5.038	<.001	.009	3	3
UCEC	GUF1 →	+0.584	+3.098	<.001	<.001	3	2
UCEC	TMEM126A →	+0.384	+2.415	.003	.003	3	2
UCEC	CTU2 →	+0.514	+2.425	<.001	.002	3	2
UCEC	NDUFAB1 →	+0.456	+2.855	.005	.001	3	2
UCEC	MTMR2 →	+0.427	+3.628	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 851 associations by consensus.

OR7A17 by HADHB expression — BLCA

Explore this box plot interactively →