HADHB

Across TCGA pan-cancer cohorts, HADHB RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated HADHB data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HADHB RNA is associated with better overall survival. In most high-consensus cancer types, elevated HADHB expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, LGG, and UVM are the cancer types where HADHB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.740	0.525	<.001	168	view →
LGG	DFS	Median	All	0.477	0.311	<.001	41	view →
UVM	DFS	Quartile	III,IV	0.170	0.792	.006	35	view →
ACC	DFS	Tertile	All	0.549	0.905	.006	31	view →
HNSC	OS	Tertile	All	0.270	0.539	.001	30	view →
MESO	OS	Tertile	IV	0.151	0.749	.006	27	view →
SKCM	OS	Tertile	All	0.260	0.394	.003	16	view →
OV	DFS	Quartile	IV	0.427	0.211	.018	12	view →
DLBC	DFS	Median	II,III,IV	1.000	0.535	.015	7	view →
COAD	OS	Median	All	0.845	0.756	.017	6	view →
LIHC	DFS	Median	All	0.398	0.230	.016	6	view →
CESC	DFS	Quartile	All	0.661	0.815	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

HADHB–KIRC (OS)

Open the KIRC breakdown →