HACL1

Across TCGA cell cohorts, HACL1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HACL1-associated genes across cancer lineages are NPY2R, C3orf85, and GJD2. Each is linked with HACL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HACL1-to-partner and partner-to-HACL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPY2R grouped by HACL1-low versus HACL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACL1→partner) and Y-score (partner→HACL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NPY2R →	+0.126	+5.539	<.001	.003	3	1
BLOOD_Leukemia	C3orf85 →	+0.025	+5.539	.004	.003	3	1
BLOOD_Lymphoma	GJD2 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	NEUROG1 →	+0.006	+5.643	<.001	.002	3	1
SKIN	MS4A6E →	+0.030	+4.415	.005	.007	3	1
LARGE_INTESTINE	FAM205C →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NPY2R by HACL1 expression — BLOOD_Leukemia

Explore this box plot interactively →