HACE1

Across TCGA pan-cancer cohorts, HACE1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HACE1 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HACE1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HACE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, KIRC, and BLCA are the cancer types where HACE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.970	0.622	.007	20	view →
KIRC	OS	Median	II,III,IV	0.170	0.696	.024	16	view →
BLCA	DFS	Median	All	1.000	0.332	.034	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →
SKCM	DFS	Median	III,IV	0.015	0.648	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HACE1–UCEC (DFS)

Open the UCEC breakdown →