HACE1

Across TCGA pan-cancer cohorts, HACE1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HACE1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HACE1 RNA is repressed in tumor relative to normal tissue. In most cancer types HACE1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where HACE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HACE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.774	<.001	10	view →
THCA	Male	II,III,IV	−0.744	<.001	8	view →
KIRC	Male	III,IV	−0.534	<.001	8	view →
LIHC	All	All	+0.290	<.001	6	view →
CHOL	All	All	+1.142	<.001	4	view →
KIRP	Male	All	−0.844	<.001	4	view →
BRCA	Female	All	−0.341	<.001	4	view →
UCEC	All	All	−0.533	.001	2	view →
LUAD	Female	II,III,IV	−0.396	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HACE1–KICH

Open the KICH breakdown →