HACE1

Across TCGA patient cohorts, HACE1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,705 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HACE1-associated genes across cancer lineages are SESN1, SEPTIN4, and SYNE1. Each is linked with HACE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HACE1-to-partner and partner-to-HACE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HACE1 versus SESN1 in OV, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACE1→partner) and Y-score (partner→HACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SESN1 →	+0.517	+0.613	.001	<.001	3	5
GBM	SEPTIN4 →	+0.589	+0.140	.003	.001	3	5
OV	SYNE1 →	+0.778	+0.555	.003	.003	3	5
CCRCC	TAL1 →	+0.972	+0.278	<.001	<.001	3	4
OV	APBB2 →	+0.679	+0.413	<.001	.001	3	4
OV	LHFPL6 →	+1.064	+0.440	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,705 associations by consensus.

HACE1 vs SESN1 — OV

Explore this scatter interactively →