HACE1

Across TCGA cell cohorts, HACE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,559 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HACE1-associated GO terms across cancer lineages are 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process, Microtubule organizing center organization, and Centrosome cycle. Each is linked with HACE1 in more than 15 cancer types. Because this analysis shows association rather than direction, both HACE1-to-partner and partner-to-HACE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process grouped by HACE1-low versus HACE1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HACE1→partner) and Y-score (partner→HACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.176	+0.998	<.001	<.001	2	16
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.083	+0.785	<.001	<.001	3	14
LUNG_SCLC	Centrosome cycle →	+0.102	+1.162	<.001	<.001	3	14
STOMACH	Hair follicle placode formation →	+0.080	+1.193	.005	<.001	3	14
LUNG_SCLC	Centrosome duplication →	+0.122	+1.050	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA damage tolerance →	+0.070	+0.641	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,559 associations by consensus.

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process by HACE1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →