HACE1

Across TCGA cell cohorts, HACE1 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HACE1-associated genes across cancer lineages are REG3G, IFNA17, and AVP. Each is linked with HACE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HACE1-to-partner and partner-to-HACE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by HACE1-low versus HACE1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACE1→partner) and Y-score (partner→HACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3G →	+0.040	+4.867	<.001	.009	3	2
LUNG_SCLC	IFNA17 →	+0.061	+5.029	.009	.006	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CABP5 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DEFB129 →	+0.043	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	MROH2B →	+0.085	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

REG3G by HACE1 expression — BLOOD_Lymphoma

Explore this box plot interactively →