H4C4

Across TCGA patient cohorts, H4C4 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible H4C4-associated genes across cancer lineages are SNORD114-2, OR8K5, and RNU6-1116P. Each is linked with H4C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C4-to-partner and partner-to-H4C4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-2 grouped by H4C4-low versus H4C4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C4→partner) and Y-score (partner→H4C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SNORD114-2 →	+0.501	+4.393	<.001	.008	3	2
SKCM	OR8K5 →	+1.910	+5.680	<.001	.003	3	2
LUAD	RNU6-1116P →	+0.315	+7.342	<.001	<.001	3	2
BLCA	PNPLA10P →	+0.041	+5.177	<.001	.007	3	2
SKCM	RNU7-23P →	+0.774	+5.771	<.001	.003	3	2
SKCM	SPCS2P2 →	+0.139	+5.594	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

SNORD114-2 by H4C4 expression — LUSC

Explore this box plot interactively →