H4C12

Across TCGA pan-cancer cohorts, H4C12 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated H4C12 data layer compared with 3 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher H4C12 RNA is associated with better overall survival. In most high-consensus cancer types, elevated H4C12 expression acts as an unfavorable survival marker, although some lineages such as SCLC and MESO show a favorable association.

SCLC, MESO, and UCEC are the cancer types where H4C12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.646	0.183	<.001	47	view →
MESO	OS	Median	All	0.482	0.291	.001	42	view →
UCEC	DFS	Quartile	All	0.589	0.729	.001	40	view →
KIRC	DFS	Median	IV	0.394	0.620	.006	29	view →
KICH	DFS	Tertile	III,IV	0.282	1.000	.012	23	view →
ACC	DFS	Quartile	All	0.285	0.884	.017	21	view →
OV	DFS	Median	IV	0.561	0.341	.002	18	view →
ESCA	DFS	Median	All	0.893	0.361	.020	18	view →
THYM	OS	Tertile	II,III,IV	0.952	0.661	.016	16	view →
SKCM	DFS	Tertile	All	0.686	0.862	.002	16	view →
PCPG	DFS	Median	All	0.976	0.813	.007	10	view →
READ	DFS	Median	IV	0.179	0.936	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

H4C12–SCLC (OS)

Open the SCLC breakdown →