H4C12

Across TCGA pan-cancer cohorts, H4C12 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of H4C12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H4C12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H4C12 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where H4C12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H4C12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.920	<.001	11	view →
LIHC	Male	II,III,IV	+1.061	<.001	9	view →
LUAD	Male	All	+1.312	<.001	8	view →
BLCA	All	All	+0.858	<.001	7	view →
BRCA	All	III,IV	+1.132	<.001	6	view →
LUSC	Male	All	+0.692	<.001	5	view →
STAD	All	All	+0.513	.015	4	view →
KICH	All	All	−0.425	.002	4	view →
KIRC	All	All	+0.310	<.001	3	view →
THCA	Male	IV	−0.669	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

H4C12–HNSC

Open the HNSC breakdown →